Medical researchers are working to develop new topical antibiotics for treating acne to replace some of those in current use. As with many other types of bacterial infections, doctors are finding that, over time, the bacteria that cause acne are becoming resistant to treatment with certain antibiotics. A different type of antibiotic or a stronger one is needed to kill disease-causing bacteria once they become resistant to existing antibiotics.

Research is being conducted on lipophilic compounds, a class of drugs that are potent in decreasing inflammation and killing P. acnes. Additional research is also being conducted on the potential side effects of isotretinoin and the long-term use of medications used for treating acne. Other researchers are attempting to determine the factors in girls during early puberty that might predict the development of severe acne later. Finally, some researchers are studying how acne affects certain aspects of patients' lives, including psychological health and quality of life.